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Fluorescent studies on the interaction of DNA and ternary lanthanide complexes with cinnamic acid‐phenanthroline and antibacterial activities testing
Author(s) -
Sun HuiJuan,
Wang AiLing,
Chu HaiBin,
Zhao YongLiang
Publication year - 2015
Publication title -
luminescence
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 45
eISSN - 1522-7243
pISSN - 1522-7235
DOI - 10.1002/bio.2701
Subject(s) - phenanthroline , lanthanide , fluorescence , chemistry , ternary operation , quenching (fluorescence) , binding constant , ternary complex , antibacterial activity , dna , cinnamic acid , photochemistry , nuclear chemistry , crystallography , stereochemistry , binding site , organic chemistry , biochemistry , bacteria , biology , ion , physics , enzyme , quantum mechanics , computer science , programming language , genetics
Twelve lanthanide complexes with cinnamate (cin – ) and 1,10‐phenanthroline (phen) were synthesized and characterized. Their compositions were assumed to be RE(cin) 3 phen (RE 3+ = La 3+ , Pr 3+ , Nd 3+ , Sm 3+ , Eu 3+ , Gd 3+ , Tb 3+ , Dy 3+ , Ho 3+ , Tm 3+ , Yb 3+ , Lu 3+ ). The interaction mode between the complexes and DNA was investigated by fluorescence quenching experiment. The results indicated the complexes could bind to DNA and the main binding mode is intercalative binding. The fluorescence quenching constants of the complexes increased from La(cin) 3 phen to Lu(cin) 3 phen. Additionally, the antibacterial activity testing showed that the complexes exhibited excellent antibacterial ability against Escherichia coli , and the changes of antibacterial ability are in agreement with that of the fluorescence quenching constants. Copyright © 2014 John Wiley & Sons, Ltd.