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Studies on the antioxidant activities of some new chromone compounds
Author(s) -
Kładna Aleksandra,
Berczyński Paweł,
Piechowska Teresa,
Kruk Irena,
AboulEnein Hassan Y.,
CeylanUnlusoy Meltem,
Verspohl Eugen J.,
Ertan Rahmiye
Publication year - 2014
Publication title -
luminescence
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 45
eISSN - 1522-7243
pISSN - 1522-7235
DOI - 10.1002/bio.2631
Subject(s) - chemistry , chromone , superoxide , radical , dpph , hydroxyl radical , antioxidant , electron paramagnetic resonance , photochemistry , chemiluminescence , reactive oxygen species , medicinal chemistry , organic chemistry , nuclear chemistry , biochemistry , nuclear magnetic resonance , enzyme , physics
Recent reviews evidence that the naturally occurring compounds containing the chromone skeleton exhibit antiradical activities, providing protection against oxidative stress. The antioxidant activities of 13 new synthesized chromonyl‐2,4‐thiazolidinediones, chromonyl‐2,4‐imidazolidinediones and chromonyl‐2‐thioxoimidzolidine‐4‐ones were evaluated using in vitro antioxidant assays, including superoxide anion radical ( O 2 − • ), hydroxyl radical ( H O • ), 2,2‐diphenyl‐1‐picryl‐hydrazyl free radical ( DPPH • ) scavenging capacity and total antioxidant capacity ferric ion reducing activity. Superoxide anion radical was produced using potassium superoxide/18‐crown‐6‐ether dissolved in dimethylsulfoxide, and the Fenton‐like reaction (Fe(II) + H 2 O 2 ) was a generator of hydroxyl radicals. Chemiluminescence, spectrophotometry, electron paramagnetic resonance (EPR) and 5,5‐dimethyl‐1‐pyrroline‐N‐oxide (DMPO) as the spin trap were the measurement techniques. The results showed that the majority of the chromone derivatives tested showed a strong scavenging effect towards free radicals, similar to the chemiluminescence reaction with superoxide anion radical with a high activity, inhibition of the DMPO‐OOH radical EPR signal (24–58%), the DMPO‐OH radical EPR signal (4–75%) and DPPH radical EPR signal (6–100%) at 1 mmol/L. Several of the examined compounds exhibited the high reduction potentials. The results obtained show that the new synthesized chromone derivatives may directly scavenger reactive oxygen species and thus may play a protective role against oxidative damage. Copyright © 2014 John Wiley & Sons, Ltd.