Flow‐injection chemiluminescence determination of acetylsalicylic acid based on its enhancing effect on the lucigenin–hydrogen peroxide system | Zendy

Wabaidur S. M. | Zendy; Alam S. M. | Zendy; Alothman Z. A. | Zendy; Eldesoky Gaber | Zendy

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Flow‐injection chemiluminescence determination of acetylsalicylic acid based on its enhancing effect on the lucigenin–hydrogen peroxide system

Author(s) -

Wabaidur S. M.,

Alam S. M.,

Alothman Z. A.,

Eldesoky Gaber

Publication year - 2014

Publication title -

luminescence

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.428

H-Index - 45

eISSN - 1522-7243

pISSN - 1522-7235

DOI - 10.1002/bio.2609

Subject(s) - lucigenin , chemiluminescence , chemistry , hydrogen peroxide , chromatography , relative standard deviation , detection limit , flow injection analysis , luminol , standard curve , organic chemistry , enzyme , superoxide

A sensitive flow‐injection chemiluminescence method for the determination of acetylsalicylic acid is described. It is based on the enhanced chemiluminescent emission of the alkaline lucigenin–H 2 O 2 system by acetylsalicylic acid. The difference in chemiluminescent intensity of alkaline lucigenin–H 2 O 2 in the presence of acetylsalicylic acid from that in the absence of acetylsalicylic acid was linear at acetylsalicylic acid concentrations in the range of 0.0029–47.37 µg/mL, with detection and quantification limits of 0.0011 and 0.0029 µg/mL , respectively. The correlation coefficient of the working curve was 0.9983. The relative standard deviation ( n = 10) for 25 µg/mL acetylsalicylic acid is 1.95%. All experimental parameters were optimized. The method was successfully applied to the determination of acetylsalicylic acid in pharmaceutical preparations. The recovery results obtained by the method were satisfactory. Copyright © 2013 John Wiley & Sons, Ltd.

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