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Free radical scavenging activity of novel thiazolidine‐2,4‐dione derivatives
Author(s) -
Berczyński Paweł,
Kruk Irena,
Piechowska Teresa,
CeylanUnlusoy Meltem,
BozdağDündar Oya,
AboulEnein Hassan Y.
Publication year - 2012
Publication title -
luminescence
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 45
eISSN - 1522-7243
pISSN - 1522-7235
DOI - 10.1002/bio.2454
Subject(s) - chemistry , electron paramagnetic resonance , radical , hydroxyl radical , superoxide , spin trapping , dpph , dimethyl sulfoxide , photochemistry , medicinal chemistry , scavenging , adduct , organic chemistry , antioxidant , enzyme , nuclear magnetic resonance , physics
Free radical activity towards superoxide anion radical ( O 2 • ¯ ), hydroxyl radical ( HO • ) and 2,2‐diphenyl‐1‐picrylhydrazyl ( DPPH • ) of a series of novel thiazolidine‐2,4‐dione derivatives (TSs) was examined using chemiluminescence, electron paramagnetic resonance (EPR) and EPR spin trapping techniques. 5,5‐Dimethyl‐1‐pyrroline‐ N ‐oxide (DMPO) was applied as the spin trap. Superoxide radical was produced in the potassium superoxide/18‐crown‐6 ether dissolved in dimethyl sulfoxide. Hydroxyl radical was generated in the Fenton reaction (Fe(II) + H 2 O 2 . It was found that TSs showed a slight scavenging effect (15–38% reduction at 2.5 mmol/L concentration) of the DPPH radical and a high scavenging effect of O 2 • ¯(41–88%). The tested compounds showed inhibition of HO • ‐dependent DMPO‐OH spin adduct formation (the amplitude of EPR signal decrease ranged from 20 to 76% at 2.5 mmol/L concentration. Our findings present new group compounds of relatively high reactivity towards free radicals. Copyright © 2012 John Wiley & Sons, Ltd.
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