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Luminometer development in the last four decades: recollections of two entrepreneurs
Author(s) -
Berthold Fritz,
Tarkkanen Veikko
Publication year - 2012
Publication title -
luminescence
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 45
eISSN - 1522-7243
pISSN - 1522-7235
DOI - 10.1002/bio.2405
Subject(s) - bioluminescence , luminescence , luciferase , chemiluminescence , firefly protocol , luminescent measurements , luciferases , adenosine triphosphate , technology development , chemistry , nanotechnology , biology , biochemistry , physics , materials science , optoelectronics , chromatography , engineering , transfection , gene , zoology , manufacturing engineering
This article, written by two entrepreneurs in luminescence, traces their involvement in the major part of the interconnected innovation and development of luminometers, adenosine triphosphate (ATP) bioluminescence and other technologies from the mid‐1970s to 2011 that ushered in much of the field of luminometry as we know it today. Key developments leading to current commercial applications of ATP bioluminescence, luminescence immunoassay, cellular luminescence, reporter gene and other applications are described from the first tube luminometers derived from early luminescence studies using liquid scintillation counting technology to measuring bioluminescence from crude ATP and firefly tail extracts. Copyright © 2012 John Wiley & Sons, Ltd.