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Determination of dipyridamole using TCPO–H 2 O 2 chemiluminescence in the presence of silver nanoparticles
Author(s) -
Wang Lijuan,
Tang Yuhai
Publication year - 2011
Publication title -
luminescence
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 45
eISSN - 1522-7243
pISSN - 1522-7235
DOI - 10.1002/bio.1301
Subject(s) - chemiluminescence , detection limit , dipyridamole , oxalate , silver nanoparticle , chemistry , relative standard deviation , redox , nanoparticle , linear range , nuclear chemistry , analytical chemistry (journal) , chromatography , materials science , inorganic chemistry , nanotechnology , medicine , radiology
The method is based on the fact that dipyridamole can enhance the chemiluminescence (CL) emission from the redox reaction of bis (2,4,6‐tricholorophenyl) oxalate (TCPO) with H 2 O 2 in the presence of silver nanoparticles (AgNPs). The CL reaction mechanism was discussed. The effect of concentrations of TCPO, H 2 O 2 , AgNPs and pH value on the CL reaction were investigated. Under the optimum conditions, the linear dynamic range was 1.0–1000 × 10 −9 g/mL and the detection limit (3 σ ) was 9 × 10 −10 g/mL. The relative standard deviation (RSD) was 4.8% for 1.0 × 10 −9 g/mL dipyridamole ( n = 7). The proposed method has been successfully applied to the determination of dipyridamole tablets and the recovery was 99–103%. Copyright © 2011 John Wiley & Sons, Ltd.