Determination of dipyridamole using TCPO–H 2 O 2 chemiluminescence in the presence of silver nanoparticles

The method is based on the fact that dipyridamole can enhance the chemiluminescence (CL) emission from the redox reaction of bis (2,4,6‐tricholorophenyl) oxalate (TCPO) with H 2 O 2 in the presence of silver nanoparticles (AgNPs). The CL reaction mechanism was discussed. The effect of concentrations of TCPO, H 2 O 2 , AgNPs and pH value on the CL reaction were investigated. Under the optimum conditions, the linear dynamic range was 1.0–1000 × 10 −9 g/mL and the detection limit (3 σ ) was 9 × 10 −10 g/mL. The relative standard deviation (RSD) was 4.8% for 1.0 × 10 −9 g/mL dipyridamole ( n  = 7). The proposed method has been successfully applied to the determination of dipyridamole tablets and the recovery was 99–103%. Copyright © 2011 John Wiley & Sons, Ltd.