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Free radical scavenging abilities of flavonyl‐thiazolidine‐2,4‐dione compounds
Author(s) -
BozdağDündar Oya,
Ertan Rahmiye,
AboulEnein Hassan Y.,
Kładna Aleksandra,
Kruk Irena
Publication year - 2011
Publication title -
luminescence
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 45
eISSN - 1522-7243
pISSN - 1522-7235
DOI - 10.1002/bio.1176
Subject(s) - chemistry , thiazolidine , dpph , scavenging , chemiluminescence , electron paramagnetic resonance , superoxide , hydroxyl radical , radical , medicinal chemistry , photochemistry , organic chemistry , antioxidant , enzyme , nuclear magnetic resonance , physics
Free radical scavenging activity of flavonyl‐thiazolidine‐2,4‐dione compounds has been evaluated using chemiluminescence, electron spin resonance spectroscopy with 5,5‐dimethyl‐1‐pyrroline‐1‐oxide as spin trap and DPPH (2,2′‐diphenyl‐1‐picrylhydrazyl) method. The examined compounds exhibited 28–50% scavenging superoxide anion radical ( ${\rm{O}}_2^{\bar\bullet}$ ), 16.7–76.7% hydroxyl radical (HO • ) and 9–40% DPPH radical. Compounds containing carbonyl group in their structure can be considered as antioxidants with high relevance and great biological importance. Copyright © 2009 John Wiley & Sons, Ltd.