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Scavenging of superoxide anion radical and hydroxyl radical by novel thiazolyl‐thiazolidine‐2,4‐dione compounds
Author(s) -
BozdağDündar Oya,
Gürkan Selen,
AboulEnein Hassan Y.,
Kruk Irena,
Kładna Aleksandra
Publication year - 2009
Publication title -
luminescence
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 45
eISSN - 1522-7243
pISSN - 1522-7235
DOI - 10.1002/bio.1095
Subject(s) - chemistry , hydroxyl radical , superoxide , spin trapping , adduct , electron paramagnetic resonance , photochemistry , radical , reactivity (psychology) , chemiluminescence , ether , radical ion , medicinal chemistry , nuclear chemistry , ion , organic chemistry , enzyme , medicine , physics , alternative medicine , nuclear magnetic resonance , pathology
The antioxidant behavior of a series of new synthesized substituted thiazolyl‐thiazolidine‐2,4‐dione compounds (TZDs) was examined using chemiluminescence and electron paramagnetic resonance spin trapping techniques. 5,5‐Dimethyl‐1‐pyrroline‐ N ‐oxide (DMPO) was used as the spin trap. The reactivity of TZDs with superoxide anion radical (O 2 • −) and hydroxyl radical (HO • ) was evaluated using potassium superoxide/18‐crown‐6 ether dissolved in dimethylsulfoxide, and the Fenton‐like reaction (Fe 2+ + H 2 O 2 ), respectively. The results showed that TZDs efficiently inhibited light emission from the O 2 • −generating system at a concentration of 0.05–1 mmol L −1 (5–94% reductions were found at 1 mmol L −1 concentration). The TZD compounds showed inhibition of HO • ‐dependent DMPO–OH spin adduct formation from DMPO (the amplitude decrease ranged from 8 to 82% at 1 mmol L −1 concentration). The findings showed that examined TZDs had effective activities as radical scavengers. Copyright © 2009 John Wiley & Sons, Ltd.