Scavenging of superoxide anion radical and hydroxyl radical by novel thiazolyl‐thiazolidine‐2,4‐dione compounds

The antioxidant behavior of a series of new synthesized substituted thiazolyl‐thiazolidine‐2,4‐dione compounds (TZDs) was examined using chemiluminescence and electron paramagnetic resonance spin trapping techniques. 5,5‐Dimethyl‐1‐pyrroline‐ N ‐oxide (DMPO) was used as the spin trap. The reactivity of TZDs with superoxide anion radical (O   2  • −) and hydroxyl radical (HO • ) was evaluated using potassium superoxide/18‐crown‐6 ether dissolved in dimethylsulfoxide, and the Fenton‐like reaction (Fe 2+  + H 2 O 2 ), respectively. The results showed that TZDs efficiently inhibited light emission from the O   2  • −generating system at a concentration of 0.05–1 mmol L −1 (5–94% reductions were found at 1 mmol L −1 concentration). The TZD compounds showed inhibition of HO • ‐dependent DMPO–OH spin adduct formation from DMPO (the amplitude decrease ranged from 8 to 82% at 1 mmol L −1 concentration). The findings showed that examined TZDs had effective activities as radical scavengers. Copyright © 2009 John Wiley & Sons, Ltd.