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Hydroxyl and superoxide radical scavenging abilities of chromonyl‐thiazolidine‐2,4‐dione compounds
Author(s) -
Kruk Irena,
BozdağDündar Oya,
Ertan Rahmiye,
AboulEnein Hassan Y.,
Michalska Teresa
Publication year - 2008
Publication title -
luminescence
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 45
eISSN - 1522-7243
pISSN - 1522-7235
DOI - 10.1002/bio.1077
Subject(s) - chemistry , radical , superoxide , chemiluminescence , electron paramagnetic resonance , adduct , hydroxyl radical , photochemistry , thiazolidine , antioxidant , spin trapping , oxygen , nuclear chemistry , organic chemistry , physics , nuclear magnetic resonance , enzyme
The oxygen free radical scavenging activities of 15 chromonyl‐thiazolidine‐2,4‐dione compounds (CTDs) were examined in chemical systems producing superoxide anion radicals, O – •2 (potasium superoxide–18‐crown‐6 ether–DMSO), and hydroxyl radicals, HO • (a Fenton reaction: Fe(II)–H 2 O 2 –sodium trifluoroacetate, pH 6.15). Chemiluminescence and electron spin resonance (ESR) spectroscopy using 5,5‐dimethyl‐1‐pyrroline‐1‐oxide (DMPO) as spin trap were applied to evaluate antioxidant behaviour of CTDs towards the oxygen radicals. The results indicated that 11 of the 15 tested compounds showed a significant inhibitory effect on the chemiluminescence generated from the O – •2 ‐generating system, ranging from 41 to 86%, and 13 CTDs quenched the ESR signal of the DMPO–OH spin adduct by 33–86%, at a concentration of 1 mmol L −1 . Our findings demonstrate that CTDs could be good free radical scavengers. Copyright © 2008 John Wiley & Sons, Ltd.