Development of a sensitive flow‐injection–chemiluminescence detection method for the determination of laevodopa | Zendy

Alam Seikh Mafiz | Zendy; Karim Mohammad Mainul | Zendy; Lee Sang Hak | Zendy; Wabaidur Saikh Mohammad | Zendy; Chung Hye Young | Zendy; Choi Jong Ha | Zendy; Kang Meea | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Development of a sensitive flow‐injection–chemiluminescence detection method for the determination of laevodopa

Author(s) -

Alam Seikh Mafiz,

Karim Mohammad Mainul,

Lee Sang Hak,

Wabaidur Saikh Mohammad,

Chung Hye Young,

Choi Jong Ha,

Kang Meea

Publication year - 2008

Publication title -

luminescence

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.428

H-Index - 45

eISSN - 1522-7243

pISSN - 1522-7235

DOI - 10.1002/bio.1039

Subject(s) - chemiluminescence , detection limit , relative standard deviation , chemistry , chromatography , correlation coefficient , flow injection analysis , analytical chemistry (journal) , urine , coefficient of variation , mathematics , biochemistry , statistics

A simple chemiluminometric method using flow injection has been developed for the determination of laevodopa, based on its sensitizing effect on the weak chemiluminescence (CL) reaction between Na 2 SO 3 and acidic KMnO 4 . Under optimum experimental conditions, the CL intensity was linearly related to the concentration of laevodopa from 3.4 × 10 –8 to 2.4 × 10 –5 mol/L and the detection limit was 1.1 × 10 –8 mol/L (s:n = 3). The relative standard deviation (RSD) of the proposed method calculated from 20 replicate injection of 3 × 10 –7 mol/L laevodopa was 3.3%. The correlation coefficient was 0.997. The method was successfully applied to the determination of laevodopa in commercial pharmaceutical formulations and spiked urine samples. Copyright © 2008 John Wiley & Sons, Ltd.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research