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Analysis of Randomized Dose‐Finding‐Studies: Closure Test Modifications Based on Multiple Contrast Tests
Author(s) -
Hothorn L. A.,
Neuhäuser M.,
Koch H.F.
Publication year - 1997
Publication title -
biometrical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 63
eISSN - 1521-4036
pISSN - 0323-3847
DOI - 10.1002/bimj.4710390408
Subject(s) - contrast (vision) , mathematics , a priori and a posteriori , closure (psychology) , statistics , multiple comparisons problem , computer science , artificial intelligence , philosophy , epistemology , economics , market economy
The power of single contrast tests strongly depends on the a priori unknown shape of the dose response relationship. Two approaches can be used to overcome this major disadvantage: the likelihood ratio test for order restriction or multiple contrast tests. Within the closure principle, the shape for the different hyptheses varies. Therefore multiple contrast tests are used as trend tests. Based on a simulation study the power advantage of this approach in comparison with single contrast tests is demonstrated.