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Modeling Exposure Intensity and Susceptibility‐Latency Effect from Retrospective Cohort Data ‐ Application to Lung Cancer Mortality in Blackfoot Disease Endemic Area in Taiwan
Author(s) -
Lee WenChung,
Lin RueyShiung
Publication year - 1996
Publication title -
biometrical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 63
eISSN - 1521-4036
pISSN - 0323-3847
DOI - 10.1002/bimj.4710380710
Subject(s) - retrospective cohort study , epidemiology , cohort , lung cancer , medicine , disease , latency stage , demography , cohort effect , latency (audio) , oncology , computer science , telecommunications , sociology
Abstract It is challenge in epidemiology to characterize the temperol aspect of exposure‐disease association. The authors propose a stochastic model to deal with exposures that are time‐dependent and exhibit susceptibility and latency effects. The model is applied to a retrospective cohort data on lung cancer mortality in the blackfoot disease endemic area in Taiwan. The authors compare the proposed model with the multistage model, the back‐calculation model, the catalytic model, and the age‐period‐cohort models.