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On Choice of Subjects and Replicates in Estimating Among and Within Subject Variation
Author(s) -
Wong Weng Kee,
Lachenbruch Peter A.,
Clements Philip J.
Publication year - 1996
Publication title -
biometrical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 63
eISSN - 1521-4036
pISSN - 0323-3847
DOI - 10.1002/bimj.4710380702
Subject(s) - variation (astronomy) , variance (accounting) , mathematics , rheumatic disease , scleroderma (fungus) , multiple sclerosis , medicine , statistics , disease , econometrics , pathology , immunology , economics , physics , accounting , inoculation , astrophysics
We consider the problem of choosing the number of replicates and number of subjects in a components of variance problem which optimizes various criteria. The case study here involves patients suffering from systemic sclerosis (Scleroderma), a form of rheumatic disease that is potentially disabling. Under the physical constraints imposed on the study, we find that using 2 or 3 replicates with as many patients as possible is the optimal strategy for several criteria.