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A New Model of Aging: Specific Versions and Their Application
Author(s) -
Yakovlev Andrej Yu,
Tsodikov Alexandr D.,
Anisimov Vladimir N.
Publication year - 1995
Publication title -
biometrical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 63
eISSN - 1521-4036
pISSN - 0323-3847
DOI - 10.1002/bimj.4710370405
Subject(s) - gompertz function , longevity , mathematics , contrast (vision) , econometrics , statistics , hazard , computer science , artificial intelligence , biology , medicine , gerontology , ecology
This paper is concerned with some versions of a stochastic model of aging proposed recently by TYURIN et al. (1993). In contrast to the commonly used Gompertz‐Makeham approach, the model yields a bounded hazard rate, thereby providing a better description of survival of old individuals in a population. Depending on plausible biological assumptions to be tested, only a few special cases of the basic model appear to be useful in experimental data analysis. We report the results of their application to experimental data on animal longevity obtained in a follow‐up study. When interpreted in terms of the model parameters, the data suggest drastically dissimilar patterns of aging for female versus male rats.