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Incorporating Prior Beliefs in Treatment Allocation for Clinical Trials
Author(s) -
Faraggi David,
Reiser Benjamin
Publication year - 1993
Publication title -
biometrical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 63
eISSN - 1521-4036
pISSN - 0323-3847
DOI - 10.1002/bimj.4710350204
Subject(s) - weighting , computer science , scheme (mathematics) , block (permutation group theory) , mathematical optimization , optimal allocation , operations research , econometrics , mathematics , medicine , mathematical analysis , geometry , radiology
Recently Faraggi and Reiser (1991) introduced a general dynamic treatment allocation scheme which incorporates the permuted block allocation procedure and the Begg Iglewicz procedure as special cases. A drawback of previous allocation methods is that they did not allow incorporation of prior knowledge of the relative importance of the prognostic factors. In this paper we extend our allocation model to incorporate the weighting of prognostic factors. A simulation study examines the effects of this procedure and an example of its implementation is given.