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Design Aspects and Odds Ratio Estimation in Multicenter Case‐Control Studies
Author(s) -
Becher H.,
Drescher K.,
Jöckel K.H.
Publication year - 1992
Publication title -
biometrical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 63
eISSN - 1521-4036
pISSN - 0323-3847
DOI - 10.1002/bimj.4710340606
Subject(s) - odds ratio , estimation , statistics , case control study , econometrics , control (management) , odds , multicenter study , computer science , mathematics , medicine , engineering , logistic regression , randomized controlled trial , artificial intelligence , systems engineering
In this paper we propose a method to be used in the planning stage of a case‐control study. An allocation rule for controls in multicenter case‐control studies is proposed which would assure a simple, efficient and unbiased estimation of the odds ratio in the pooled data. It is shown that the efficiency of the design increases with increasing correlation between study center and risk factor. Sources of bias and their implications for relative risk estimation are discussed. The method is demonstrated with data from a case‐control study.