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Estimatien of Infectious Potential of Blood Containing Human Immunodeficiency Virus
Author(s) -
Connett J. E.,
Rhame F. S.,
Thomas J.,
Le Ch. T.
Publication year - 1990
Publication title -
biometrical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 63
eISSN - 1521-4036
pISSN - 0323-3847
DOI - 10.1002/bimj.4710320703
Subject(s) - human immunodeficiency virus (hiv) , virology , maximum likelihood , medicine , statistics , mathematics
A method is described for estimating the probability that transfusion of a given quantity of blood from an AIDS‐infected donor will result in infection in the recipient. The method is based on maximum likelihood, and requires the assumption that individual viruses act independently in causing infection. Results of simulations indicate that the resulting estimates have low bias. The method is applicable to a wide variety of other problems.