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Binary Data in Prerandomized Designs
Author(s) -
Bernhard G.,
Compag D.
Publication year - 1989
Publication title -
biometrical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 63
eISSN - 1521-4036
pISSN - 0323-3847
DOI - 10.1002/bimj.4710310104
Subject(s) - randomized controlled trial , binary data , selection (genetic algorithm) , binary number , mathematics , statistics , simple (philosophy) , research design , completely randomized design , computer science , medicine , arithmetic , artificial intelligence , surgery , philosophy , epistemology
In 1979 and 1981 Zelen introduced the so‐called prerandomized designs as an alternative to the completely randomized trial of therapies: The participants of the trial are first (pre‐) randomized to the treatment groups and asked afterwards for their consent. In the case of binary data, tests for selection and treatment effects in the simple and double prerandomized design are derived and then illustrated by a numerical example.