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Estimation and Tests of Mendelian Inheritance in Small Samples of Human Families
Author(s) -
Bchini M.,
Goux J. M.
Publication year - 1988
Publication title -
biometrical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 63
eISSN - 1521-4036
pISSN - 0323-3847
DOI - 10.1002/bimj.4710300610
Subject(s) - mendelian inheritance , estimation , statistics , sample size determination , maximum likelihood , inheritance (genetic algorithm) , sample (material) , mathematics , econometrics , genetics , biology , engineering , gene , chemistry , systems engineering , chromatography
Estimation of parameters in human genetics is usually performed by Maximum Likelihood methods for large samples relying on asymptotic results. With the aim of evaluating the importance of the bias resulting from sample size, two sets of human family data have been analysed. The bias is not very important, but programs have been elaborated, giving better estimations. The tests of hypotheses from these estimations have also been considered.