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Complex Segregation Analysis on Sib‐Pairs Data
Author(s) -
Tai J. J.,
Gross Alan J.
Publication year - 1988
Publication title -
biometrical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 63
eISSN - 1521-4036
pISSN - 0323-3847
DOI - 10.1002/bimj.4710300309
Subject(s) - locus (genetics) , trait , computation , mathematics , maximum likelihood , statistics , genetics , computer science , algorithm , biology , gene , programming language
Using sib‐pairs and parent‐pairs data, a quantitative trait can be tested for the existence of a major locus under the mixed model of Morton and MacLean (1974). The basic idea is to obtain the two conditional likelihoods for sib‐pair differences and parent‐pair differences provided that it is known which sib‐pairs or parent‐pairs have the same effect at the major locus. Two conditions are introduced to obtain two recursive computer algorithms that distinguish the sib‐pairs or parent‐pairs having the same effect at the major locus. This method has the advantage of reducing complicated computations involving maximum likelihood estimates from nuclear families. A simulation experiment is performed to illustrate the method and its results are discussed.