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A Theoretical Model for Estimating Linkage in F 2 Populations with Distorted Single Gene Segregation
Author(s) -
Heun M.,
Gregorius H.R.
Publication year - 1987
Publication title -
biometrical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 63
eISSN - 1521-4036
pISSN - 0323-3847
DOI - 10.1002/bimj.4710290403
Subject(s) - selection (genetic algorithm) , penetrance , linkage (software) , biology , genetics , genetic linkage , zygote , locus (genetics) , recombination , maximum likelihood , gene , evolutionary biology , phenotype , statistics , mathematics , computer science , artificial intelligence , embryogenesis
A model is presented which allows estimation of linkage from dihybrid F 2 populations with distorted single gene segregation by applying the maximum‐likelihood method. For different selection processes operating on one locus at either the gametic or the zygotic level, it can be demonstrated that, if the deficit is previously taken into account, testing for free recombination can be carried out without prior knowledge of the causes of this deficit. In the presence of linkage, the expected frequencies of two phenotypic classes depend on whether gametic or zygotic selection is operating. The remaining two classes can be utilized for the estimation of linkage as their frequency ratio is independent of these selection types. The application of this procedure to situations with coupling, incomplete penetrance, gametic and zygotic selection is discussed.