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A Relationship Between two Fundamental Concepts in Drug Combination Theory
Author(s) -
Wolf Th.,
Unkelbach H. D.
Publication year - 1986
Publication title -
biometrical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 63
eISSN - 1521-4036
pISSN - 0323-3847
DOI - 10.1002/bimj.4710280108
Subject(s) - additive function , simple (philosophy) , similarity (geometry) , mathematics , line (geometry) , econometrics , statistical physics , computer science , epistemology , artificial intelligence , physics , mathematical analysis , philosophy , geometry , image (mathematics)
Theories for the dose response analysis of drug combinations have been developed along two separate lines. In the first line, mainly followed by pharmacologists, the concept of “additivity” is of central importance. A corresponding central concept in the second line, which was mainly followed by biometricians, is that of “simple similarity”. We show that simple similarity implies additivity and we give a condition under which the reverse holds.