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Models of Independent Action for Combination Therapy
Author(s) -
Korn E. L.
Publication year - 1985
Publication title -
biometrical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 63
eISSN - 1521-4036
pISSN - 0323-3847
DOI - 10.1002/bimj.4710270711
Subject(s) - outcome (game theory) , logistic regression , action (physics) , disease , statistics , mathematics , econometrics , medicine , mathematical economics , physics , quantum mechanics
Two methods of applying Finney's concept of simple independent action are suggested for examining possible synergism in combination therapy. In one model the treatments act independently at one time to cure the disease. In the other model the treatments act independently continuously to prevent the disease from progressing to a terminal outcome. The implications of these models for the interaction terms of a proportional hazards model, a log‐linear model on death rates, and a logistic model are discussed.