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The Concept of Additivity of Drug Combinations in the Case of Quantal Response
Author(s) -
Wolf Th.,
Unkelbach H.D.
Publication year - 1985
Publication title -
biometrical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 63
eISSN - 1521-4036
pISSN - 0323-3847
DOI - 10.1002/bimj.4710270419
Subject(s) - additive function , mathematics , statistics , econometrics , toxicology , biology , mathematical analysis
The concept of additivity of drug combinations is widely accepted in pharmacology and toxicology. Up to now, no general statistical methods to test that property are available. The present paper gives a mathematical formulation of additivity, a method to fit dose response surfaces under additivity assumption and a statistical test.