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On the C OLTON Model for Clinical Trials with Delayed Observations‐Dichotomous Responses
Author(s) -
Langenberg P.,
Srinivasan R.
Publication year - 1982
Publication title -
biometrical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 63
eISSN - 1521-4036
pISSN - 0323-3847
DOI - 10.1002/bimj.4710240314
Subject(s) - clinical trial , medicine , time horizon , statistics , econometrics , mathematics , mathematical optimization
In the C OLTON model for clinical trials a choice is to be made between two medical treatments where there is a known patient horizon N . In an earlier paper we studied the C OLTON model under the additional assumption that there is a time lag between the administration of the treatments and the availability of the responses where the responses are normally distributed. Here we extend the results of the earlier paper to the case where responses are dichotomous. The relative performance of two simple procedures for dealing with the patients who arrive during the waiting period between the end of the administration of treatment in the trial phase and observation of the final trial response is discussed within a B AYESIAN framework.