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Sample Sizes in Sequential Survival Clinical Trials
Author(s) -
Nagelkerke N. J. D.,
Hart A. A. M.,
Strackee J.
Publication year - 1981
Publication title -
biometrical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 63
eISSN - 1521-4036
pISSN - 0323-3847
DOI - 10.1002/bimj.4710230711
Subject(s) - sample size determination , clinical trial , survival analysis , medicine , statistics , mathematics
In survival clinical trials the response, i.e. (time to) death is delayed. As a result there are at any time patients that have not responded, yet. Given a stopping rule based on the number of deaths, the distribution of the total number of patients that will enter the trial is examined. Besides, a simple approximation to the expected number of patients is presented.