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A multivariate generalization of the FRIEDMAN rank test with application to a problem in molecular biology
Author(s) -
Koziol J. A.,
Smith C. I.
Publication year - 1980
Publication title -
biometrical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 63
eISSN - 1521-4036
pISSN - 0323-3847
DOI - 10.1002/bimj.4710220802
Subject(s) - generalization , multivariate statistics , rank (graph theory) , multivariate analysis , test (biology) , biology , series (stratigraphy) , statistics , computational biology , mathematics , combinatorics , ecology , mathematical analysis , paleontology
A series of experiments was recently undertaken at the National Institutes of Health to ascertain whether tRNA populations are determined by or adapted to the major proteins synthesized by tumor cells. Dissimilarity indices between chromatographic profiles of animoacyl‐tRNAs from 11 mouse plasmacytomas and from normal adult mouse liver and brain were calculated and then compared using a multivariate generalization of the FRIEDMAN rank test. This test is described herein, and its use is illustrated with data from the experiments.