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On a stochastic model of a molecular genetic system capable of differentiation and reproduction of the initial state
Author(s) -
Tchuraev R. N.
Publication year - 1980
Publication title -
biometrical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 63
eISSN - 1521-4036
pISSN - 0323-3847
DOI - 10.1002/bimj.4710220212
Subject(s) - cell division , division (mathematics) , somatic cell , state (computer science) , reproduction , biology , cell fate determination , computer science , cell , genetics , mathematics , biological system , gene , algorithm , arithmetic , transcription factor
A model of the system, consisting of a cyclic 3‐operonic subsystem, related to a 2‐operonic trigger by direct and feedback connections, is built. The operons of this system are functionally connected by repressers. The basic postulates are: a) the repressers are stable; b) during cell division each molecule of represser and respective mRNA has equal probability to find itself in any daughter cell. Computer simulation demonstrates that after few cell divisions, analogues of somatic cell, maintaining the system for some successive divisions, and of generative cells, where by the system returns to the initial state, appear. A scheme of molecular genetic control system, producing a lot of different cell types in course of successive cell divisions, is proposed.