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Focused information criterion on predictive models in personalized medicine
Author(s) -
Yang Hui,
Liu Yutao,
Liang Hua
Publication year - 2015
Publication title -
biometrical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 63
eISSN - 1521-4036
pISSN - 0323-3847
DOI - 10.1002/bimj.201400106
Subject(s) - personalized medicine , computer science , predictive modelling , information criteria , machine learning , model selection , selection (genetic algorithm) , data mining , demographics , artificial intelligence , statistics , mathematics , bioinformatics , demography , sociology , biology
Instead of assessing the overall fit of candidate models like the traditional model selection criteria, the focused information criterion focuses attention directly on the parameter of the primary interest and aims to select the model with the minimum estimated mean squared error for the estimate of the focused parameter. In this article we apply the focused information criterion for personalized medicine. By using individual‐level information from clinical observations, demographics, and genetics, we obtain the personalized predictive models to make the prognosis and diagnosis individually. The consideration of the heterogeneity among the individuals helps reduce the prediction uncertainty and improve the prediction accuracy. Two real data examples from biomedical research are studied as illustrations.