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Sample size re‐estimation in clinical trials
Author(s) -
Proschan Michael A.
Publication year - 2009
Publication title -
biometrical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 63
eISSN - 1521-4036
pISSN - 0323-3847
DOI - 10.1002/bimj.200800266
Subject(s) - sample size determination , estimation , flexibility (engineering) , computer science , outcome (game theory) , sample (material) , clinical trial , statistics , adaptive design , econometrics , medicine , mathematics , engineering , chemistry , systems engineering , mathematical economics , chromatography
Adaptive clinical trials are becoming very popular because of their flexibility in allowing mid‐stream changes of sample size, endpoints, populations, etc . At the same time, they have been regarded with mistrust because they can produce bizarre results in very extreme settings. Understanding the advantages and disadvantages of these rapidly developing methods is a must. This paper reviews flexible methods for sample size re‐estimation when the outcome is continuous.