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A Point Estimator for the Time Course of Drug Release
Author(s) -
KoehneVoss Stephan,
Pigeot Iris
Publication year - 2009
Publication title -
biometrical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 63
eISSN - 1521-4036
pISSN - 0323-3847
DOI - 10.1002/bimj.200710498
Subject(s) - deconvolution , estimator , interval estimation , variance (accounting) , mathematics , point estimation , interval (graph theory) , point (geometry) , pharmacokinetics , statistics , computer science , mathematical optimization , algorithm , confidence interval , medicine , pharmacology , accounting , combinatorics , business , geometry
Procedures for deconvolution of pharmacokinetic data are routinely used in the pharmaceutical industry to determine drug release and absorption which is essential in designing optimized drug formulations. Although these procedures are described extensively in the pharmacokinetic literature, they have been studied less from a statistical point of view and variance estimation has not been addressed. We discuss the statistical properties of a numerical procedure for deconvolution. Based on a point‐area deconvolution method we define an estimator for the function that describes the time course of drug release from a drug formulation. Asymptotic distributions are derived and several methods of variance and interval estimation are compared (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)