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Comparison of ROC Umbrella Volumes with an Application to the Assessment of Lung Cancer Diagnostic Markers
Author(s) -
Alonzo Todd A.,
Nakas Christos T.
Publication year - 2007
Publication title -
biometrical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 63
eISSN - 1521-4036
pISSN - 0323-3847
DOI - 10.1002/bimj.200610363
Subject(s) - receiver operating characteristic , lung cancer , identification (biology) , cancer , medicine , oncology , statistics , mathematics , biology , botany
Receiver operating characteristic (ROC) analysis is widely used to assess the ability of diagnostic markers to correctly classify into one of two disease classes. ROC surfaces and umbrella surfaces generalize the utility of ROC analysis when there are three disease classes. Identification of lung cancer diagnostic markers is an active area of research since prognosis for those diagnosed with lung cancer is so poor and there is not an accurate method for early detection of lung cancer. A study conducted for the assessment of DNA methylation markers motivated the comparison of ROC umbrella surfaces which is developed in this article using U‐statistics and bootstrap methodology. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)