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Multiple Targeted Therapies: Is there a Place for Vach Type‐3 or Type‐4 Design Trials
Author(s) -
Hasenclever Dirk
Publication year - 2006
Publication title -
biometrical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 63
eISSN - 1521-4036
pISSN - 0323-3847
DOI - 10.1002/bimj.200610298
Subject(s) - clinical trial , medicine , clinical study design , type (biology) , set (abstract data type) , computer science , biology , ecology , programming language
Invited comment on Vach W. and dePoint Christensen R. (2006). Making efficient use of patients in designing phase III trials investigating simultaneously a set of targeted therapies with different targets, Biometrical Journal 48 , 897–907. For complexity reasons the designs proposed by Vach et al. will probably not be used in initial drug registration trials. But they may be an option for established study groups that run treatment‐optimisation or indication‐extension trials investigating targeted drugs that are already registered. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)