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Analysis of Relation between Virologic Responses and Immunologic Responses, Patient's Factors in AIDS Clinical Trials Using – A Semiparametric Mixed‐Effects Model
Author(s) -
Liang Hua,
Zou Guohua
Publication year - 2007
Publication title -
biometrical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 63
eISSN - 1521-4036
pISSN - 0323-3847
DOI - 10.1002/bimj.200610294
Subject(s) - semiparametric regression , semiparametric model , inference , clinical trial , viral load , parametric statistics , nonparametric statistics , medicine , regression analysis , immunology , statistics , mathematics , computer science , human immunodeficiency virus (hiv) , artificial intelligence
In this article we propose to use a semiparametric mixed‐effects model based on an exploratory analysis of clinical trial data for a study of the relation between virologic responses and immunologic markers such as CD4+ and CD8 counts, and host‐specific factors in AIDS clinical trials. The regression spline technique, used for inference for parameters in the model, reduces the unknown nonparametric components to parametric functions. It is simple and straightforward to implement the procedures using readily available software, and parameter inference can be developed from standard parametric models. We apply the model and the proposed method to an AIDS clinical study. Our findings indicate that viral load level is positively related to baseline viral load level, negatively related to CD4+ cell counts, but unrelated to CD8 cell counts and patient's age neither. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)