Confirmatory Seamless Phase II/III Clinical Trials with Hypotheses Selection at Interim: Opportunities and Limitations | Zendy

Jennison Christopher | Zendy; Turnbull Bruce W. | Zendy

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Confirmatory Seamless Phase II/III Clinical Trials with Hypotheses Selection at Interim: Opportunities and Limitations

Author(s) -

Jennison Christopher,

Turnbull Bruce W.

Publication year - 2006

Publication title -

biometrical journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.108

H-Index - 63

eISSN - 1521-4036

pISSN - 0323-3847

DOI - 10.1002/bimj.200610248

Subject(s) - interim , selection (genetic algorithm) , clinical trial , interim analysis , confirmatory factor analysis , econometrics , psychology , computer science , medicine , artificial intelligence , machine learning , economics , structural equation modeling , political science , law

This is a discussion of the following two papers in this special issue on adaptive designs: ‘Confirmatory seamless phase II/III clinical trials with hypotheses selection at interim: General concepts’ by Frank Bretz, Heinz Schmidli, Franz König, Amy Racine and Willi Maurer, and ‘Confirmatory seamless phase II/III clinical trials with hypotheses selection at interim: Applications and practical considerations’ by Heinz Schmidli, Frank Bretz, Amy Racine and Willi Maurer. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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