Plan to be Flexible: A Commentary on Adaptive Designs | Zendy

Shih Weichung Joe | Zendy

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Plan to be Flexible: A Commentary on Adaptive Designs

Author(s) -

Shih Weichung Joe

Publication year - 2006

Publication title -

biometrical journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.108

H-Index - 63

eISSN - 1521-4036

pISSN - 0323-3847

DOI - 10.1002/bimj.200610241

Subject(s) - interim , selection (genetic algorithm) , adaptive design , computer science , clinical trial , econometrics , psychology , operations research , artificial intelligence , medicine , economics , mathematics , political science , law

This is a discussion of the following three papers appearing in this special issue on adaptive designs: ‘Nested repeated confidence intervals and switching between noninferiority and superiority’ by Joachim Hartung and Guido Knapp; ‘Confirmatory Seamless Phase II/III Clinical trials with Hypotheses Selection at Interim: General Concepts’ by Frank Bretz, Heinz Schmidli, Franz König, Amy Racine and Willi Maurer; and ‘Confirmatory Seamless Phase II/III Clinical Trials with Hypotheses Selection at Interim: Applications and Practical Considerations’ by Heinz Schmidli, Frank Bretz, Amy Racine and Willi Maurer. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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