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The Likelihood as Statistical Evidence in Multiple Comparisons in Clinical Trials: No Free Lunch
Author(s) -
Korn Edward L.,
Freidlin Boris
Publication year - 2006
Publication title -
biometrical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 63
eISSN - 1521-4036
pISSN - 0323-3847
DOI - 10.1002/bimj.200510216
Subject(s) - statistics , econometrics , mathematics
The likelihood ratio summarizes the strength of statistical evidence for one simple pre‐determined hypothesis versus another. However, it does not directly address the multiple comparisons problem. In this paper we discuss some concerns related to the application of likelihood ratio methods to several multiple comparisons issues in clinical trials, in particular, subgroup analysis, multiple variables, interim monitoring, and data driven choice of hypotheses. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)