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S15.3: Is Helicobacter pylori infection a necessary condition for non‐cardia gastric cancer?
Author(s) -
Brenner Hermann,
Arndt Volker,
Stegmaier Christa,
Ziegler Hartwig,
Rothenbacher Dietrich
Publication year - 2004
Publication title -
biometrical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 63
eISSN - 1521-4036
pISSN - 0323-3847
DOI - 10.1002/bimj.200490235
Subject(s) - citation , helicobacter pylori infection , cancer , library science , medicine , helicobacter pylori , computer science
68 patients with gastric cancer and 360 controls were recruited in a population-based case-control study in Saarland/Germany between 11/1996 and 2/1998. Personal interviews were conducted and serum samples were taken during first hospitalization due to the cancer. Serum samples were analysed for H pylori specific IgG antibodies by ELISA (GAP, Bio-Rad, München, Germany) and for antibodies against the CagA antigen by Western blot (AID, Strasberg, Germany). Cases were compared to controls with respect to serological evidence of H pylori infection and CagA positivity in the entire sample and after (consecutive) exclusion of subgroups among whom H pylori test results might not adequately indicate previous H pylori exposure. Results