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Significance Tests in Mutagen Screening: Another Method Considering Historical Control Frequencies
Author(s) -
Traut H.
Publication year - 1983
Publication title -
biometrical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 63
eISSN - 1521-4036
pISSN - 0323-3847
DOI - 10.1002/bimj.19830250710
Subject(s) - mutation frequency , mutagen , control (management) , statistics , computer science , mathematics , mutation , biology , genetics , artificial intelligence , dna , gene
Recently a method has been devised for testing the significance of the difference between a mutation frequency observed after chemical treatment or irradiation and the historical (“stable”) control frequency. In the present communication another test is proposed serving the same purpose. Both methods are applied to several examples (experimental frequency versus historical control frequency). The results ( P values) obtained agree well.