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Proliferating cell nuclear antigen: More than a clamp for DNA polymerases
Author(s) -
Jónsson Zophonías O.,
Hübscher Ulrich
Publication year - 1997
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950191106
Subject(s) - proliferating cell nuclear antigen , dna polymerase , biology , dna replication , eukaryotic dna replication , dna polymerase delta , replication factor c , dna clamp , dna repair , replication protein a , microbiology and biotechnology , dna polymerase ii , control of chromosome duplication , dna , genetics , dna binding protein , rna , reverse transcriptase , gene , transcription factor
Abstract DNA metabolic events such as replication, repair and recombination require the concerted action of several enzymes and cofactors. Nature has provided a set of proteins that support DNA polymerases in performing processive, accurate and rapid DNA synthesis. Two of them, the proliferating cell nuclear antigen and its adapter protein replication factor C, cooperate to form a moving platform that was initially thought of only as an anchor point for DNA polymerases δ and ε. It now appears that proliferating cell nuclear antigen is also a communication point between a variety of important cellular processes including cell cycle control, DNA replication, nucleotide excision repair, post‐replication mismatch repair, base excision repair and at least one apoptotic pathway. The dynamic movement of proliferating cell nuclear antigen on and off the DNA renders this protein an ideal communicator for a variety of proteins that are essential for DNA metabolic events in eukaryotic cells.