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A crystal milestone: The structure of regulated Src
Author(s) -
SupertiFurga Giulio,
Gonfloni Stefania
Publication year - 1997
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950190602
Subject(s) - milestone , proto oncogene tyrosine protein kinase src , phosphorylation , signal transduction , sh3 domain , tyrosine , biology , kinase , microbiology and biotechnology , computational biology , biochemistry , history , archaeology
The viral and cellular forms of the Src protein tyrosine kinases take a prototypic role in oncology and signal transduction research, by virtue of being holders of an impressive number of ‘firsts’. Our understanding of the biochemistry and physiology of Src has therefore always been used as a reference for our general advancement in the field of protein phosphorylation and growth control. The recent solution of the crystal structure of two members of the Src family (1,2) represents a milestone in these disciplines and, as usual, provides a general lookout post for developments to come.