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Telomeres, not the end of the story
Author(s) -
Gotta Monica,
Cockell Moira
Publication year - 1997
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950190503
Subject(s) - telomere , heterochromatin , biology , nucleosome , chromatin , budding yeast , subtelomere , genetics , euchromatin , eukaryotic chromosome fine structure , yeast , rap1 , gene , dna , transcription (linguistics) , microbiology and biotechnology , saccharomyces cerevisiae , telomere binding protein , transcription factor , dna binding protein , linguistics , philosophy
Transcription in organisms as diverse as yeast and mammals is subject to chromosomal position effects that result in heritable and variegated patterns of gene expression. Two recent studies have employed a reversible protein‐DNA crosslinking method to identify the structural components of heterochromatin in budding yeast (1,2) . The results show that a complex containing the proteins Rap1, Sir2p, Sir3p and Sir4p is physically associated with nucleosomes at telomere proximal regions, but that the repressive chromatin structure extended by Sir3p overexpression has a different composition.