Premium
Mechanism of gene expression by the glucocorticoid receptor: Role of protein‐protein interactions
Author(s) -
McEwan Iain J.,
Wright Anthony P. H.,
Gustafsson JanÅke
Publication year - 1997
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950190210
Subject(s) - glucocorticoid receptor , transcription coregulator , nuclear receptor coactivator 2 , transcription factor , biology , general transcription factor , pelp 1 , microbiology and biotechnology , taf2 , response element , liver receptor homolog 1 , chromatin , 5 ht5a receptor , hormone response element , transcription (linguistics) , genetics , nuclear receptor , gene expression , gene , promoter , transcriptional regulation , enhancer , estrogen receptor , linguistics , philosophy , cancer , breast cancer
The glucocorticoid receptor belongs to an important class of transcription factors that alter the expression of target genes in response to a specific hormone signal. The glucocorticoid receptor can function at least at three levels: (1) recruitment of the general transcription machinery; (2) modulation of transcription factor action, independent of DNA binding, through direct protein‐protein interactions; and (3) modulation of chromatin structure to allow the assembly of other gene regulatory proteins and/or the general transcription machinery on the DNA. This review will focus on the multifaceted nature of protein‐protein interactions involving the glucocorticoid receptor and basal transcription factors, coactivators and other transcription factors, occurring at these different levels of regulation.