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Wnt signalling goes nuclear
Author(s) -
Kühl Michael,
Wedlich Doris
Publication year - 1997
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950190204
Subject(s) - wnt signaling pathway , xenopus , transcription factor , microbiology and biotechnology , biology , nucleus , beta catenin , signalling , cell nucleus , signal transduction , genetics , gene
The Wnt signalling cascade is a highly conserved signalling pathway throughout the animal kingdom. In Xenopus , Wnt signalling functions in mesodermal dorsoventral patterning. Earlier work on deciphering the components of the wnt signalling cascade left a gap between cytosolic β‐catenin, the final member of the cascade, and the nuclear target genes. Several recent papers now reveal how the Wnt signal is transmitted into the nucleus. Surprisingly, β‐catenin directly interacts with the transcription factor LEF‐1/XTCF‐3, and thereby is not only translocated into the nucleus but also modulates the properties of LEF‐1/XTCF‐3 as a transcription factor (1–5) .