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Author(s) -
Hartl Daniel L.
Publication year - 1996
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950181213
Subject(s) - biology , gene , genetics , phenotype , drosophila (subgenus) , human genome , candidate gene , genome , computational biology
A recently published study (1) has identified a set of candidate genes for human diseases based on findings from Drosophila . Each human expressed sequence tag (EST) in a large database was compared with all known Drosophila genes. After eliminating matches between genes of already known function, the remaining sequences were mapped in the human genome. In each region, the phenotypes of all known human diseases were compared with the phenotypes of known Drosophila mutations in order to identify candidate genes for the human diseases. Are the correspondences real or coincidental?