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Cdc6 and DNA replication: Limited to humble origins
Author(s) -
Heichman Karen A.
Publication year - 1996
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950181103
Subject(s) - control of chromosome duplication , origin recognition complex , minichromosome maintenance , eukaryotic dna replication , pre replication complex , dna re replication , dna replication , dna replication factor cdt1 , replication factor c , biology , licensing factor , microbiology and biotechnology , s phase , origin of replication , genetics , dna
The budding yeast Cdc6 protein is important for regulating DNA replication intiation. Cdc6p acts at replication origins, and cdc6‐1 mutants arrest with unreplicated DNA and show elevated minichromosome loss rates. Overexpression of the related Cdc 18 protein in fission yeast results in DNA rereplication; however, Cdc6p overexpression does not cause this result. A recent paper (1) further defines the role of Cdc6p in DNA replication. Cdc6p only promotes DNA replication between the end of mitosis and late G 1 , and although the Cdc6 protein is highly unstable, neither degradation nor nuclear localization is critical for limiting DNA replication to this interval.