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The coming of age of ventralising homeobox genes in amphibian development
Author(s) -
Lemaire Patrick
Publication year - 1996
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950180904
Subject(s) - homeobox , xenopus , amphibian , homeobox a1 , biology , embryo , transcription factor , dlx5 , microbiology and biotechnology , cdx2 , gene , dorsum , transcription (linguistics) , emx2 , homeobox protein nkx 2.5 , anatomy , genetics , ecology , linguistics , philosophy
The emerging view of early dorso‐ventral patterning of amphibian embryos is that two opposing gradients of dorsalising and ventralising secreted factors are necessary. while several transcription factors acting upstream or downstream of the dorsalising molecules have been identified, until recently little was known about the transcriptional response to ventralising signals. Now two groups describe the identification of related homeodomain proteins, Xvent‐1 and Vox , which are able to convert dorsal cells of Xenopus embryos into more ventral ones (1,2) .