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Molecular mechanisms of durg inhibition of DNA gyrase
Author(s) -
Lewis Richard J.,
Tsai Francis T. F.,
Wigley Dale B.
Publication year - 1996
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950180810
Subject(s) - dna gyrase , dna , biology , genetics , computational biology , microbiology and biotechnology , gene , escherichia coli
DNA gyrase, an enzyme unique to prokaryotes, has been implicated in almost all processes that involve DNA. Although efficient inhibitors of this protein have been known for more than 20 years, none of them have enjoyed prolonged pharmaceutical success. It is only recently that the mechanisms of inhibition for some of these classes of drugs have been established unequivocally by X‐ray crystallography. It is hoped that this detailed structural information will assist the design of novel, effective inhibitors of DNA gyrase.