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Promiscuity of fibroblast growth factor receptors
Author(s) -
Green Paula J.,
Walsh Frank S.,
Doherty Patrick
Publication year - 1996
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950180807
Subject(s) - fibroblast growth factor receptor , fibroblast growth factor , biology , microbiology and biotechnology , receptor tyrosine kinase , fibroblast growth factor receptor 1 , receptor , signal transduction , genetics
Fibroblast growth factor receptors (FGFRs) have been implicated in many developmental and regenerative events, including axial organisation, mesodermal patterning, keratinocyte organisation and brain development. The consensus view that this reflects a role for one or other of the nine known members of the fibroblast growth factor family in these processes has recently been challenged by the suggestion that FGFRs might be directly activated by a much wider range of ligands, including heparan sulphate proteoglycans and neural cell adhesion molecules. In addition, two novel soluble ligands for FGFRs have been identified using yeast two‐hybrid technology. Overall, the new findings suggest that in terms of ligand binding the FGFRs might be an even more promiscuous family of receptor tyrosine kinases than was already appreciated.