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Dynamic property of intermediate filaments: Regulation by phosphorylation
Author(s) -
Inagaki Masaki,
Matsuoka Yoichiro,
Tsujimura Kunio,
Ando Shoji,
Tokui Toshiya,
Takahashi Toshitada,
Inagaki Naoyuki
Publication year - 1996
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950180610
Subject(s) - phosphorylation , serine , microbiology and biotechnology , intracellular , threonine , protein phosphorylation , mitosis , kinase , protein filament , biology , biochemistry , chemistry , protein kinase a
Site‐specific phosphorylation of intermediate filament (IF) proteins on serine and threonine residues leads to alteration of the filament structure, in vitro and in vivo . Protein kinases involved in cell signaling and those activated in mitosis dynamically control spatial and temporal organization of intracellular IF phosphorylation. Thus, IF phosphorylation appears to be one of the most predominant strategies in coordinating intracellular organization of the IF network.